Trissel's Stability of Compounded Formulations

Trissel's Stability of Compounded Formulations serves as a reference guide for pharmacists and healthcare professionals who prepare compounded medications. The book provides data on chemical and physical stability for various pharmaceutical compounds and formulations. The text includes extensive research on beyond-use dating, storage requirements, and compatibility information for drugs used in compounding practice. Each entry contains stability data derived from published studies and scientific literature, organized alphabetically by drug name for quick reference. Technical specifications cover pH ranges, concentration limits, container materials, and environmental factors that affect drug stability. The reference also addresses proper documentation practices and quality control procedures for compounding facilities. This guide represents a foundation text for evidence-based pharmaceutical compounding, emphasizing patient safety through precise formulation stability data. Its systematic approach to stability information makes it an essential resource for modern compounding practice.

Pharmacists and compounding professionals report using this reference regularly in their daily practice. Readers value the stability data tables, evidence-based beyond-use dating information, and comprehensive documentation of storage conditions. Likes: - Organization by drug name makes lookup fast - Includes pH stability ranges and degradation factors - References are thoroughly cited - Updated with current USP standards - Digital/ebook version enables quick searching Dislikes: - High price point (~$200) - Some stability data comes from older studies - A few readers note gaps for newer compounds - Print size can be small in physical edition Ratings: Amazon: 4.7/5 (89 reviews) Goodreads: 4.5/5 (12 reviews) Specific feedback: "Use it multiple times daily" - Hospital pharmacist on Amazon "Worth the investment but expensive" - Compound pharmacy technician "Missing some newer biologics" - Clinical pharmacist review

Handbook on Injectable Drugs by Lawrence A. Trissel This reference contains data on drug compatibility and stability for injectable medications used in clinical practice.

Pharmaceutical Calculations by Howard C. Ansel The text provides formulation calculations and compounding principles for pharmaceutical preparations.

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Remington: The Science and Practice of Pharmacy by David B. Troy, Paul Beringer This comprehensive text covers pharmaceutical principles, compounding practices, and formulation science.

Pharmaceutical Compounding and Dispensing by John F. Marriott and Keith A. Wilson The text provides formulation methods and stability considerations for compounded pharmaceutical preparations.

🔬 First published in 1996, this book has become the go-to resource for pharmacists determining beyond-use dates for compounded medications, helping prevent medication errors and ensure patient safety. ⚗️ Lawrence A. Trissel served as the Director of Clinical Pharmaceutics Research at The University of Texas M.D. Anderson Cancer Center, where he conducted groundbreaking research on drug stability and compatibility. 🧪 The book contains stability information for over 170 drugs that can be compounded into oral, topical, and injectable preparations—data that took decades of research to compile. 💊 Each new edition undergoes rigorous peer review by practicing pharmacists and includes the latest research on drug stability in various environments, temperatures, and container types. 🏥 The stability guidelines in this book are recognized by the United States Pharmacopeia (USP) and are used as reference standards by regulatory bodies across the United States.